Longevity Insights & Analysis

Three recent studies suggest that lithium, psilocybin, and ezetimibe—three very different drugs—may share a surprising longevity-enhancing mechanism: boosting telomerase activity and preserving telomere length. This emerging research links mood stabilizers, psychedelics, and cholesterol drugs to slower cellular aging and reduced Alzheimer’s risk, revealing a powerful case for repurposing existing drugs in longevity medicine.

We’ve spent years debating whether aging is a disease—but that’s the wrong question. The real challenge is recognizing when the diseases of aging begin to take root. Longevity medicine looks beneath the surface, using biomarkers to detect early physiological drift and intervene before symptoms appear. With tools to measure biological age, we can finally shift from treating disease to preserving vitality and extending healthspan.

A Harvard study reveals lithium orotate may be a breakthrough in protecting the aging brain. Unlike lithium carbonate, which requires high doses and carries toxicity risks, lithium orotate crosses the blood-brain barrier in microdoses. Early findings show it blocks amyloid and tau buildup, restores memory in mice, promotes neurogenesis, reduces inflammation, and may slow or prevent Alzheimer’s disease.

Could a common cholesterol drug help protect the brain? My latest post explores new research on Zetia (ezetimibe) and its surprising link to Alzheimer’s risk, from large patient studies to animal data on memory and brain health. I also share my own experience with the drug—and why I’m considering giving it another try.

Testosterone therapy isn’t just about fixing low levels—it’s about helping men thrive as they age. Research now shows optimized testosterone supports muscle, metabolism, mood, and even longevity, without the cardiovascular or prostate risks once feared. Instead of waiting for ‘abnormal’ numbers, we should monitor and optimize earlier, aiming for vitality, strength, and healthier aging.

A Mayo Clinic study shows balance may be the clearest sign of aging—more so than strength or gait. After my own spinal surgery, I’ve seen how vital it is. One-leg balance, especially on the non-dominant side, predicts longevity and daily function. The good news? Practicing it improves it. Balance isn’t just a test—it’s training for a longer, healthier life.