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Published by Dr. Raffaele

A natural product telomerase activator as part of a health maintenance program.
Harley CB, Liu W, Blasco M, Vera E, Andrews WH, Briggs LA, Raffaele JM..
A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study.
Salvador L, Singaravelu G, Harley CB, Flom P, Suram A, Raffaele JM. Rejuvenation Res Dec 2016

Biomarkers of Aging: General considerations and composite indices

Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures.
Karasik D, Demissie S, Cupples LA, Kiel DP.. J Gerontol A Biol Sci Med Sci. May 2005
Biomarkers of aging: from primitive organisms to humans.
Butler RN, Sprott R, Warner H, et al.. J Gerontol A Biol Sci Med Sci. Jun 2004
Biological age--what is it and can it be measured?
Jackson SH, Weale MR, Weale RA.. Arch Gerontol Geriatr Mar-Apr 2003

Pulmonary System Aging

COPD as a disease of accelerated lung aging.
Kazuhiro Ito, Peter J Barnes. Chest Jan 2009
John Hutchinson's mysterious machine revisited
Thomas L Petty. Chest May 2002
Reduced pulmonary function is associated with central arterial stiffness in men
M Zureik, A Benetos, C Neukirch, D Courbon, K Bean, F Thomas, P Ducimetière. Am J Respir Crit Care Med Dec 2001
Decline in lung function and mortality: the Busselton Health Study
Lung function, respiratory symptoms, and mortality: results from the Busselton Health Study
Knuiman MW, James AL, Divitini ML, Ryan G, Bartholomew HC, Musk AW. .
Spirometric Reference Values from a Sample of the General U.S. Population
Mortality associated with respiratory function and symptoms in advanced age. The Framingham Study

Skin Aging

Estrogens and the skin
Brincat MP, Baron YM, Galea R. Climacteric June 2005
Effects of aging and postmenopausal hypoestrogenism on skin elasticity and bone mineral density in Japanese women
Hiroyuki Sumino, Shuichi Ichikawa, Masahiko Kurabayashi. Endocrine Journal April 2004
Effects of aging, menopause, and hormone replacement therapy on forearm skin elasticity in women
Hiroyuki Sumino, Shuichi Ichikawa ... Masahiko Kurabayashi. Journal of American Geriatrics Society June 2004
Skin biophysical properties of a population living in Valais, Switzerland
Pierre-André Wendling, Giorgio Dell'Acqua. Skin Res. Technology November, 2003
Mechanisms of Photoaging and Chronological Skin Aging
Gary J Fisher, Sewon Kang ... John J Voorhees. Arch Dermatol Nov 2002
Ageing and rheological properties of facial skin in women
G E Piérard, F Henry ... G Ries. Gerontology 1998
Treatment of skin aging with topical estrogens
J B Schmidt, M Binder ... A Reiner. International Journal of Dermatology September, 1996

Cognitive Aging

Age-associated cognitive decline
Deary IJ, Corley J, Gow AJ, et al. Br Med Bull 2009
Insights into the ageing mind: a view from cognitive neuroscience
Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate
Dehydroepiandrosterone (DHEA): a misunderstood adrenal hormone and spine-tingling neurosteroid?
Estrogen and cognition: a true relationship?
All in your mind.
Cognitive effects of short-term manipulation of serum sex steroids in healthy young men
Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges
Insulin-like growth factor-I and cognitive function in healthy older men

Immune System Aging

CD28(-) T cells: their role in the age-associated decline of immune function
Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals.
Mechanisms of immunosenescence. Immun Ageing
No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study
Telomerase induction in T cells: a cure for aging and disease?
CD8 T-cell immune phenotype of successful aging
Immunity challenge

Telomere Attrition and Aging

Telomere length and risk of incident cancer and cancer mortality.
Willeit P, Willeit J, Mayr A, et al.. JAMA July 2010
Cytomegalovirus infection reduces telomere length of the circulating T cell pool
van de Berg PJ, Griffiths SJ, Yong SL, et al. J Immunol 2010
A Natural Product Telomerase Activator as Part of a Health Maintenance Program
Harley CB, Liu W, Blasco M, et al. Rejuvenation Res 2010
Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis
Brouilette SW, Whittaker A, Stevens SE, van der Harst P, Goodall AH, Samani NJ. Heart 2008
Telomeres and aging
Aubert G, Lansdorp PM. Physiol Rev April 2008
Leukocyte telomere length and cardiovascular disease in the cardiovascular health study
Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Am J Epidemiol 2007
Telomere length, stem cells and aging
Blasco MA. Nat Chem Biol 2007
Telomeres and human somatic fitness
Aviv A. J Gerontol A Biol Sci Med Sci 2006